Publications

Publications2019-03-26T17:43:04+00:00

2019

Bandopadhayay, P, Piccioni, F, O'Rourke, R, Ho, P, Gonzalez, EM, Buchan, G, Qian, K, Gionet, G, Girard, E, Coxon, M, Rees, MG, Brenan, L, Dubois, F, Shapira, O, Greenwald, NF, Pages, M, Balboni Iniguez, A, Paolella, BR, Meng, A, Sinai, C, Roti, G, Dharia, NV, Creech, A, Tanenbaum, B, Khadka, P, Tracy, A, Tiv, HL, Hong, AL, Coy, S, Rashid, R, Lin, JR, Cowley, GS, Lam, FC, Goodale, A, Lee, Y, Schoolcraft, K, Vazquez, F, Hahn, WC, Tsherniak, A, Bradner, JE, Yaffe, MB, Milde, T, Pfister, SM, Qi, J, Schenone, M, Carr, SA, Ligon, KL, Kieran, MW, Santagata, S, Olson, JM et al.. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019;10 (1):2400.
PubMed PMID:31160565

Ghandi, M, Huang, FW, Jané-Valbuena, J, Kryukov, GV, Lo, CC, McDonald, ER 3rd, Barretina, J, Gelfand, ET, Bielski, CM, Li, H, Hu, K, Andreev-Drakhlin, AY, Kim, J, Hess, JM, Haas, BJ, Aguet, F, Weir, BA, Rothberg, MV, Paolella, BR, Lawrence, MS, Akbani, R, Lu, Y, Tiv, HL, Gokhale, PC, de Weck, A, Mansour, AA, Oh, C, Shih, J, Hadi, K, Rosen, Y, Bistline, J, Venkatesan, K, Reddy, A, Sonkin, D, Liu, M, Lehar, J, Korn, JM, Porter, DA, Jones, MD, Golji, J, Caponigro, G, Taylor, JE, Dunning, CM, Creech, AL, Warren, AC, McFarland, JM, Zamanighomi, M, Kauffmann, A, Stransky, N, Imielinski, M et al.. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019;569 (7757):503-508.
PubMed PMID:31068700

Li, BT, Janku, F, Jung, B, Hou, C, Madwani, K, Alden, R, Razavi, P, Reis-Filho, JS, Shen, R, Isbell, JM, Blocker, AW, Eattock, N, Gnerre, S, Satya, RV, Xu, H, Zhao, C, Hall, MP, Hu, Y, Sehnert, AJ, Brown, D, Ladanyi, M, Rudin, CM, Hunkapiller, N, Feeney, N, Mills, GB, Paweletz, CP, Janne, PA, Solit, DB, Riely, GJ, Aravanis, A, Oxnard, GR. Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium. Ann. Oncol. 2019;30 (4):597-603.
PubMed PMID:30891595

Konstantinopoulos, PA, Barry, WT, Birrer, M, Westin, SN, Cadoo, KA, Shapiro, GI, Mayer, EL, O'Cearbhaill, RE, Coleman, RL, Kochupurakkal, B, Whalen, C, Curtis, J, Farooq, S, Luo, W, Eismann, J, Buss, MK, Aghajanian, C, Mills, GB, Palakurthi, S, Kirschmeier, P, Liu, J, Cantley, LC, Kaufmann, SH, Swisher, EM, D'Andrea, AD, Winer, E, Wulf, GM, Matulonis, UA. Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. Lancet Oncol. 2019;20 (4):570-580.
PubMed PMID:30880072

Liang, L, Peng, Y, Zhang, J, Zhang, Y, Roy, M, Han, X, Xiao, X, Sun, S, Liu, H, Nie, L, Kuang, Y, Zhu, Z, Deng, J, Xia, Y, Sankaran, VG, Hillyer, CD, Mohandas, N, Ye, M, An, X, Liu, J. Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1. Haematologica. 2019; :.
PubMed PMID:30872372

Hong, AL, Tseng, YY, Wala, JA, Kim, WJ, Kynnap, BD, Doshi, MB, Kugener, G, Sandoval, GJ, Howard, TP, Li, J, Yang, X, Tillgren, M, Ghandi, M, Sayeed, A, Deasy, R, Ward, A, McSteen, B, Labella, KM, Keskula, P, Tracy, A, Connor, C, Clinton, CM, Church, AJ, Crompton, BD, Janeway, KA, Van Hare, B, Sandak, D, Gjoerup, O, Bandopadhayay, P, Clemons, PA, Schreiber, SL, Root, DE, Gokhale, PC, Chi, SN, Mullen, EA, Roberts, CW, Kadoch, C, Beroukhim, R, Ligon, KL, Boehm, JS, Hahn, WC. Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. Elife. 2019;8 :.
PubMed PMID:30860482

Howard, TP, Arnoff, TE, Song, MR, Giacomelli, AO, Wang, X, Hong, AL, Dharia, NV, Wang, S, Vazquez, F, Pham, MT, Morgan, AM, Wachter, F, Bird, GH, Kugener, G, Oberlick, EM, Rees, MG, Tiv, HL, Hwang, JH, Walsh, KH, Cook, A, Krill-Burger, JM, Tsherniak, A, Gokhale, PC, Park, PJ, Stegmaier, K, Walensky, LD, Hahn, WC, Roberts, CWM. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Res. 2019;79 (9):2404-2414.
PubMed PMID:30755442

Miret, JJ, Kirschmeier, P, Koyama, S, Zhu, M, Li, YY, Naito, Y, Wu, M, Malladi, VS, Huang, W, Walker, W, Palakurthi, S, Dranoff, G, Hammerman, PS, Pecot, CV, Wong, KK, Akbay, EA. Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. J Immunother Cancer. 2019;7 (1):32.
PubMed PMID:30728077

Iavarone, C, Zervantonakis, IK, Selfors, LM, Palakurthi, S, Liu, JF, Drapkin, R, Matulonis, UA, Hallberg, D, Velculescu, VE, Leverson, JD, Sampath, D, Mills, GB, Brugge, JS. Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol. Cancer Ther. 2019;18 (3):642-655.
PubMed PMID:30679390

Park, DE, Cheng, J, Berrios, C, Montero, J, Cortés-Cros, M, Ferretti, S, Arora, R, Tillgren, ML, Gokhale, PC, DeCaprio, JA. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (3):1027-1032.
PubMed PMID:30598450

Kitajima, S, Ivanova, E, Guo, S, Yoshida, R, Campisi, M, Sundararaman, SK, Tange, S, Mitsuishi, Y, Thai, TC, Masuda, S, Piel, BP, Sholl, LM, Kirschmeier, PT, Paweletz, CP, Watanabe, H, Yajima, M, Barbie, DA. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Cancer Discov. 2019;9 (1):34-45.
PubMed PMID:30297358

2018

Zeng, M, Kwiatkowski, NP, Zhang, T, Nabet, B, Xu, M, Liang, Y, Quan, C, Wang, J, Hao, M, Palakurthi, S, Zhou, S, Zeng, Q, Kirschmeier, PT, Meghani, K, Leggett, AL, Qi, J, Shapiro, GI, Liu, JF, Matulonis, UA, Lin, CY, Konstantinopoulos, PA, Gray, NS. Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. Elife. 2018;7 :.
PubMed PMID:30422115

Sade-Feldman, M, Yizhak, K, Bjorgaard, SL, Ray, JP, de Boer, CG, Jenkins, RW, Lieb, DJ, Chen, JH, Frederick, DT, Barzily-Rokni, M, Freeman, SS, Reuben, A, Hoover, PJ, Villani, AC, Ivanova, E, Portell, A, Lizotte, PH, Aref, AR, Eliane, JP, Hammond, MR, Vitzthum, H, Blackmon, SM, Li, B, Gopalakrishnan, V, Reddy, SM, Cooper, ZA, Paweletz, CP, Barbie, DA, Stemmer-Rachamimov, A, Flaherty, KT, Wargo, JA, Boland, GM, Sullivan, RJ, Getz, G, Hacohen, N. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175 (4):998-1013.e20.
PubMed PMID:30388456

Fitarelli-Kiehl, M, Yu, F, Ashtaputre, R, Leong, KW, Ladas, I, Supplee, J, Paweletz, C, Mitra, D, Schoenfeld, JD, Parangi, S, Makrigiorgos, GM. Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies. Clin. Chem. 2018;64 (12):1762-1771.
PubMed PMID:30274976

Lizotte, PH, Hong, RL, Luster, TA, Cavanaugh, ME, Taus, LJ, Wang, S, Dhaneshwar, A, Mayman, N, Yang, A, Kulkarni, M, Badalucco, L, Fitzpatrick, E, Kao, HF, Kuraguchi, M, Bittinger, M, Kirschmeier, PT, Gray, NS, Barbie, DA, Jänne, PA. A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing. Cancer Immunol Res. 2018;6 (12):1511-1523.
PubMed PMID:30242021

Kitajima, S, Asahina, H, Chen, T, Guo, S, Quiceno, LG, Cavanaugh, JD, Merlino, AA, Tange, S, Terai, H, Kim, JW, Wang, X, Zhou, S, Xu, M, Wang, S, Zhu, Z, Thai, TC, Takahashi, C, Wang, Y, Neve, R, Stinson, S, Tamayo, P, Watanabe, H, Kirschmeier, PT, Wong, KK, Barbie, DA. Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS. Cancer Cell. 2018;34 (3):439-452.e6.
PubMed PMID:30205046

Aref, AR, Campisi, M, Ivanova, E, Portell, A, Larios, D, Piel, BP, Mathur, N, Zhou, C, Coakley, RV, Bartels, A, Bowden, M, Herbert, Z, Hill, S, Gilhooley, S, Carter, J, Cañadas, I, Thai, TC, Kitajima, S, Chiono, V, Paweletz, CP, Barbie, DA, Kamm, RD, Jenkins, RW. 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade. Lab Chip. 2018;18 (20):3129-3143.
PubMed PMID:30183789

Adeegbe, DO, Liu, S, Hattersley, MM, Bowden, M, Zhou, CW, Li, S, Vlahos, R, Grondine, M, Dolgalev, I, Ivanova, EV, Quinn, MM, Gao, P, Hammerman, PS, Bradner, JE, Diehl, JA, Rustgi, AK, Bass, AJ, Tsirigos, A, Freeman, GJ, Chen, H, Wong, KK. BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer. Cancer Immunol Res. 2018;6 (10):1234-1245.
PubMed PMID:30087114

Kuang, Y, Siddiqui, B, Hu, J, Pun, M, Cornwell, M, Buchwalter, G, Hughes, ME, Wagle, N, Kirschmeier, P, Jänne, PA, Paweletz, CP, Lin, NU, Krop, IE, Barry, WT, Winer, EP, Brown, M, Jeselsohn, R. Unraveling the clinicopathological features driving the emergence of ESR1 mutations in metastatic breast cancer. NPJ Breast Cancer. 2018;4 :22.
PubMed PMID:30083595

Oxnard, GR, Hu, Y, Mileham, KF, Husain, H, Costa, DB, Tracy, P, Feeney, N, Sholl, LM, Dahlberg, SE, Redig, AJ, Kwiatkowski, DJ, Rabin, MS, Paweletz, CP, Thress, KS, Jänne, PA. Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib. JAMA Oncol. 2018;4 (11):1527-1534.
PubMed PMID:30073261

Bahcall, M, Awad, MM, Sholl, LM, Wilson, FH, Xu, M, Wang, S, Palakurthi, S, Choi, J, Ivanova, EV, Leonardi, GC, Ulrich, BC, Paweletz, CP, Kirschmeier, PT, Watanabe, M, Baba, H, Nishino, M, Nagy, RJ, Lanman, RB, Capelletti, M, Chambers, ES, Redig, AJ, VanderLaan, PA, Costa, DB, Imamura, Y, Jänne, PA. Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer. Clin. Cancer Res. 2018;24 (23):5963-5976.
PubMed PMID:30072474

Cañadas, I, Thummalapalli, R, Kim, JW, Kitajima, S, Jenkins, RW, Christensen, CL, Campisi, M, Kuang, Y, Zhang, Y, Gjini, E, Zhang, G, Tian, T, Sen, DR, Miao, D, Imamura, Y, Thai, T, Piel, B, Terai, H, Aref, AR, Hagan, T, Koyama, S, Watanabe, M, Baba, H, Adeni, AE, Lydon, CA, Tamayo, P, Wei, Z, Herlyn, M, Barbie, TU, Uppaluri, R, Sholl, LM, Sicinska, E, Sands, J, Rodig, S, Wong, KK, Paweletz, CP, Watanabe, H, Barbie, DA. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nat. Med. 2018;24 (8):1143-1150.
PubMed PMID:30038220

Guibert, N, Tsukada, H, Hwang, DH, Chambers, E, Cibas, ES, Bale, T, Supplee, J, Ulrich, B, Sholl, LM, Paweletz, CP, Oxnard, GR. Liquid biopsy of fine-needle aspiration supernatant for lung cancer genotyping. Lung Cancer. 2018;122 :72-75.
PubMed PMID:30032849

Oxnard, GR, Paweletz, CP. Regarding the Congruence Between 2 Circulating Tumor DNA Sequencing Assays. JAMA Oncol. 2018;4 (10):1428-1429.
PubMed PMID:30027282

Hanna, GJ, Supplee, JG, Kuang, Y, Mahmood, U, Lau, CJ, Haddad, RI, Jänne, PA, Paweletz, CP. Plasma HPV cell-free DNA monitoring in advanced HPV-associated oropharyngeal cancer. Ann. Oncol. 2018;29 (9):1980-1986.
PubMed PMID:30010779

Li, S, Liu, S, Deng, J, Akbay, EA, Hai, J, Ambrogio, C, Zhang, L, Zhou, F, Jenkins, RW, Adeegbe, DO, Gao, P, Wang, X, Paweletz, CP, Herter-Sprie, GS, Chen, T, Gutiérrez-Quiceno, L, Zhang, Y, Merlino, AA, Quinn, MM, Zeng, Y, Yu, X, Liu, Y, Fan, L, Aguirre, AJ, Barbie, DA, Yi, X, Wong, KK. Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer. Clin. Cancer Res. 2018;24 (19):4854-4864.
PubMed PMID:29945997

Kuang, Y, O’Connell, A, Sacher, AG, Feeney, N, Alden, RS, Oxnard, GR, Paweletz, CP. Monitoring of Response and Resistance in Plasma of EGFR-Mutant Lung Cancer Using Droplet Digital PCR. Methods Mol. Biol. 2018;1768 :193-207.
PubMed PMID:29717445

Odegaard, JI, Vincent, JJ, Mortimer, S, Vowles, JV, Ulrich, BC, Banks, KC, Fairclough, SR, Zill, OA, Sikora, M, Mokhtari, R, Abdueva, D, Nagy, RJ, Lee, CE, Kiedrowski, LA, Paweletz, CP, Eltoukhy, H, Lanman, RB, Chudova, DI, Talasaz, A. Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies. Clin. Cancer Res. 2018;24 (15):3539-3549.
PubMed PMID:29691297

Liu, HJ, Lizotte, PH, Du, H, Speranza, MC, Lam, HC, Vaughan, S, Alesi, N, Wong, KK, Freeman, GJ, Sharpe, AH, Henske, EP. TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. JCI Insight. 2018;3 (8):.
PubMed PMID:29669930

Hu, Y, Ulrich, BC, Supplee, J, Kuang, Y, Lizotte, PH, Feeney, NB, Guibert, NM, Awad, MM, Wong, KK, Jänne, PA, Paweletz, CP, Oxnard, GR. False-Positive Plasma Genotyping Due to Clonal Hematopoiesis. Clin. Cancer Res. 2018;24 (18):4437-4443.
PubMed PMID:29567812

Hanna, GJ, Lizotte, P, Cavanaugh, M, Kuo, FC, Shivdasani, P, Frieden, A, Chau, NG, Schoenfeld, JD, Lorch, JH, Uppaluri, R, MacConaill, LE, Haddad, RI. Frameshift events predict anti-PD-1/L1 response in head and neck cancer. JCI Insight. 2018;3 (4):.
PubMed PMID:29467336

Yanagita, M, Luke, JJ, Hodi, FS, Jänne, PA, Paweletz, CP. Isolation and characterization of circulating melanoma cells by size filtration and fluorescent in-situ hybridization. Melanoma Res. 2018;28 (2):89-95.
PubMed PMID:29406397

Guibert, N, Hu, Y, Feeney, N, Kuang, Y, Plagnol, V, Jones, G, Howarth, K, Beeler, JF, Paweletz, CP, Oxnard, GR. Amplicon-based next-generation sequencing of plasma cell-free DNA for detection of driver and resistance mutations in advanced non-small cell lung cancer. Ann. Oncol. 2018;29 (4):1049-1055.
PubMed PMID:29325035

Deng, J, Wang, ES, Jenkins, RW, Li, S, Dries, R, Yates, K, Chhabra, S, Huang, W, Liu, H, Aref, AR, Ivanova, E, Paweletz, CP, Bowden, M, Zhou, CW, Herter-Sprie, GS, Sorrentino, JA, Bisi, JE, Lizotte, PH, Merlino, AA, Quinn, MM, Bufe, LE, Yang, A, Zhang, Y, Zhang, H, Gao, P, Chen, T, Cavanaugh, ME, Rode, AJ, Haines, E, Roberts, PJ, Strum, JC, Richards, WG, Lorch, JH, Parangi, S, Gunda, V, Boland, GM, Bueno, R, Palakurthi, S, Freeman, GJ, Ritz, J, Haining, WN, Sharpless, NE, Arthanari, H, Shapiro, GI, Barbie, DA, Gray, NS, Wong, KK. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018;8 (2):216-233.
PubMed PMID:29101163

Jenkins, RW, Aref, AR, Lizotte, PH, Ivanova, E, Stinson, S, Zhou, CW, Bowden, M, Deng, J, Liu, H, Miao, D, He, MX, Walker, W, Zhang, G, Tian, T, Cheng, C, Wei, Z, Palakurthi, S, Bittinger, M, Vitzthum, H, Kim, JW, Merlino, A, Quinn, M, Venkataramani, C, Kaplan, JA, Portell, A, Gokhale, PC, Phillips, B, Smart, A, Rotem, A, Jones, RE, Keogh, L, Anguiano, M, Stapleton, L, Jia, Z, Barzily-Rokni, M, Cañadas, I, Thai, TC, Hammond, MR, Vlahos, R, Wang, ES, Zhang, H, Li, S, Hanna, GJ, Huang, W, Hoang, MP, Piris, A, Eliane, JP, Stemmer-Rachamimov, AO, Cameron, L, Su, MJ et al.. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018;8 (2):196-215.
PubMed PMID:29101162

Ulrich, BC, Paweletz, CP. Cell-Free DNA in Oncology: Gearing up for Clinic. Ann Lab Med. 2018;38 (1):1-8.
PubMed PMID:29071812

2017

Kedves, AT, Gleim, S, Liang, X, Bonal, DM, Sigoillot, F, Harbinski, F, Sanghavi, S, Benander, C, George, E, Gokhale, PC, Nguyen, QD, Kirschmeier, PT, Distel, RJ, Jenkins, J, Goldberg, MS, Forrester, WC. Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C. J. Clin. Invest. 2017;127 (12):4554-4568.
PubMed PMID:29130934

Hu, Y, Alden, RS, Odegaard, JI, Fairclough, SR, Chen, R, Heng, J, Feeney, N, Nagy, RJ, Shah, J, Ulrich, B, Gutierrez, M, Lanman, RB, Garber, JE, Paweletz, CP, Oxnard, GR. Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients. Clin. Cancer Res. 2017;23 (23):7351-7359.
PubMed PMID:28947568

Mita, MM, Mita, AC, Moseley, JL, Poon, J, Small, KA, Jou, YM, Kirschmeier, P, Zhang, D, Zhu, Y, Statkevich, P, Sankhala, KK, Sarantopoulos, J, Cleary, JM, Chirieac, LR, Rodig, SJ, Bannerji, R, Shapiro, GI. Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies. Br. J. Cancer. 2017;117 (9):1258-1268.
PubMed PMID:28859059

Zervantonakis, IK, Iavarone, C, Chen, HY, Selfors, LM, Palakurthi, S, Liu, JF, Drapkin, R, Matulonis, U, Leverson, JD, Sampath, D, Mills, GB, Brugge, JS. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nat Commun. 2017;8 (1):365.
PubMed PMID:28848242

Jeselsohn, R, Cornwell, M, Pun, M, Buchwalter, G, Nguyen, M, Bango, C, Huang, Y, Kuang, Y, Paweletz, C, Fu, X, Nardone, A, De Angelis, C, Detre, S, Dodson, A, Mohammed, H, Carroll, JS, Bowden, M, Rao, P, Long, HW, Li, F, Dowsett, M, Schiff, R, Brown, M. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (22):E4482-E4491.
PubMed PMID:28507152

Adeegbe, DO, Liu, Y, Lizotte, PH, Kamihara, Y, Aref, AR, Almonte, C, Dries, R, Li, Y, Liu, S, Wang, X, Warner-Hatten, T, Castrillon, J, Yuan, GC, Poudel-Neupane, N, Zhang, H, Guerriero, JL, Han, S, Awad, MM, Barbie, DA, Ritz, J, Jones, SS, Hammerman, PS, Bradner, J, Quayle, SN, Wong, KK. Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer. Cancer Discov. 2017;7 (8):852-867.
PubMed PMID:28408401

Zhang, H, Fillmore Brainson, C, Koyama, S, Redig, AJ, Chen, T, Li, S, Gupta, M, Garcia-de-Alba, C, Paschini, M, Herter-Sprie, GS, Lu, G, Zhang, X, Marsh, BP, Tuminello, SJ, Xu, C, Chen, Z, Wang, X, Akbay, EA, Zheng, M, Palakurthi, S, Sholl, LM, Rustgi, AK, Kwiatkowski, DJ, Diehl, JA, Bass, AJ, Sharpless, NE, Dranoff, G, Hammerman, PS, Ji, H, Bardeesy, N, Saur, D, Watanabe, H, Kim, CF, Wong, KK. Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Nat Commun. 2017;8 :14922.
PubMed PMID:28387316

Hanna, GJ, Liu, H, Jones, RE, Bacay, AF, Lizotte, PH, Ivanova, EV, Bittinger, MA, Cavanaugh, ME, Rode, AJ, Schoenfeld, JD, Chau, NG, Haddad, RI, Lorch, JH, Wong, KK, Uppaluri, R, Hammerman, PS. Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck. Oral Oncol. 2017;67 :61-69.
PubMed PMID:28351582

Matulonis, UA, Wulf, GM, Barry, WT, Birrer, M, Westin, SN, Farooq, S, Bell-McGuinn, KM, Obermayer, E, Whalen, C, Spagnoletti, T, Luo, W, Liu, H, Hok, RC, Aghajanian, C, Solit, DB, Mills, GB, Taylor, BS, Won, H, Berger, MF, Palakurthi, S, Liu, J, Cantley, LC, Winer, E. Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer. Ann. Oncol. 2017;28 (3):512-518.
PubMed PMID:27993796

Tolaney, SM, Ziehr, DR, Guo, H, Ng, MR, Barry, WT, Higgins, MJ, Isakoff, SJ, Brock, JE, Ivanova, EV, Paweletz, CP, Demeo, MK, Ramaiya, NH, Overmoyer, BA, Jain, RK, Winer, EP, Duda, DG. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. Oncologist. 2017;22 (1):25-32.
PubMed PMID:27789775

Liu, JF, Palakurthi, S, Zeng, Q, Zhou, S, Ivanova, E, Huang, W, Zervantonakis, IK, Selfors, LM, Shen, Y, Pritchard, CC, Zheng, M, Adleff, V, Papp, E, Piao, H, Novak, M, Fotheringham, S, Wulf, GM, English, J, Kirschmeier, PT, Velculescu, VE, Paweletz, C, Mills, GB, Livingston, DM, Brugge, JS, Matulonis, UA, Drapkin, R. Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin. Cancer Res. 2017;23 (5):1263-1273.
PubMed PMID:27573169

Oxnard, GR, Paweletz, CP, Sholl, LM. Genomic Analysis of Plasma Cell-Free DNA in Patients With Cancer. JAMA Oncol. 2017;3 (6):740-741.
PubMed PMID:27541382

2016

Awad, MM, Jones, RE, Liu, H, Lizotte, PH, Ivanova, EV, Kulkarni, M, Herter-Sprie, GS, Liao, X, Santos, AA, Bittinger, MA, Keogh, L, Koyama, S, Almonte, C, English, JM, Barlow, J, Richards, WG, Barbie, DA, Bass, AJ, Rodig, SJ, Hodi, FS, Wucherpfennig, KW, Jänne, PA, Sholl, LM, Hammerman, PS, Wong, KK, Bueno, R. Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors. Cancer Immunol Res. 2016;4 (12):1038-1048.
PubMed PMID:27856426

Lizotte, PH, Ivanova, EV, Awad, MM, Jones, RE, Keogh, L, Liu, H, Dries, R, Almonte, C, Herter-Sprie, GS, Santos, A, Feeney, NB, Paweletz, CP, Kulkarni, MM, Bass, AJ, Rustgi, AK, Yuan, GC, Kufe, DW, Jänne, PA, Hammerman, PS, Sholl, LM, Hodi, FS, Richards, WG, Bueno, R, English, JM, Bittinger, MA, Wong, KK. Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes. JCI Insight. 2016;1 (14):e89014.
PubMed PMID:27699239

Bahcall, M, Sim, T, Paweletz, CP, Patel, JD, Alden, RS, Kuang, Y, Sacher, AG, Kim, ND, Lydon, CA, Awad, MM, Jaklitsch, MT, Sholl, LM, Jänne, PA, Oxnard, GR. Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer. Cancer Discov. 2016;6 (12):1334-1341.
PubMed PMID:27694386

Lizotte, PH, Jones, RE, Keogh, L, Ivanova, E, Liu, H, Awad, MM, Hammerman, PS, Gill, RR, Richards, WG, Barbie, DA, Bass, AJ, Bueno, R, English, JM, Bittinger, M, Wong, KK. Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment. Sci Rep. 2016;6 :31745.
PubMed PMID:27539742

Oxnard, GR, Thress, KS, Alden, RS, Lawrance, R, Paweletz, CP, Cantarini, M, Yang, JC, Barrett, JC, Jänne, PA. Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer. J. Clin. Oncol. 2016;34 (28):3375-82.
PubMed PMID:27354477

Yanagita, M, Redig, AJ, Paweletz, CP, Dahlberg, SE, O’Connell, A, Feeney, N, Taibi, M, Boucher, D, Oxnard, GR, Johnson, BE, Costa, DB, Jackman, DM, Jänne, PA. A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non-Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II Trial. Clin. Cancer Res. 2016;22 (24):6010-6020.
PubMed PMID:27281561

Jia, Y, Yun, CH, Park, E, Ercan, D, Manuia, M, Juarez, J, Xu, C, Rhee, K, Chen, T, Zhang, H, Palakurthi, S, Jang, J, Lelais, G, DiDonato, M, Bursulaya, B, Michellys, PY, Epple, R, Marsilje, TH, McNeill, M, Lu, W, Harris, J, Bender, S, Wong, KK, Jänne, PA, Eck, MJ. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016;534 (7605):129-32.
PubMed PMID:27251290

Sacher, AG, Paweletz, C, Dahlberg, SE, Alden, RS, O’Connell, A, Feeney, N, Mach, SL, Jänne, PA, Oxnard, GR. Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer. JAMA Oncol. 2016;2 (8):1014-22.
PubMed PMID:27055085

Wang, S, Blois, A, El Rayes, T, Liu, JF, Hirsch, MS, Gravdal, K, Palakurthi, S, Bielenberg, DR, Akslen, LA, Drapkin, R, Mittal, V, Watnick, RS. Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med. 2016;8 (329):329ra34.
PubMed PMID:26962158

Koyama, S, Akbay, EA, Li, YY, Herter-Sprie, GS, Buczkowski, KA, Richards, WG, Gandhi, L, Redig, AJ, Rodig, SJ, Asahina, H, Jones, RE, Kulkarni, MM, Kuraguchi, M, Palakurthi, S, Fecci, PE, Johnson, BE, Janne, PA, Engelman, JA, Gangadharan, SP, Costa, DB, Freeman, GJ, Bueno, R, Hodi, FS, Dranoff, G, Wong, KK, Hammerman, PS. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun. 2016;7 :10501.
PubMed PMID:26883990

Karlovich, C, Goldman, JW, Sun, JM, Mann, E, Sequist, LV, Konopa, K, Wen, W, Angenendt, P, Horn, L, Spigel, D, Soria, JC, Solomon, B, Camidge, DR, Gadgeel, S, Paweletz, C, Wu, L, Chien, S, O’Donnell, P, Matheny, S, Despain, D, Rolfe, L, Raponi, M, Allen, AR, Park, K, Wakelee, H. Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686). Clin. Cancer Res. 2016;22 (10):2386-95.
PubMed PMID:26747242

Maxson, JE, Abel, ML, Wang, J, Deng, X, Reckel, S, Luty, SB, Sun, H, Gorenstein, J, Hughes, SB, Bottomly, D, Wilmot, B, McWeeney, SK, Radich, J, Hantschel, O, Middleton, RE, Gray, NS, Druker, BJ, Tyner, JW. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. Cancer Res. 2016;76 (1):127-38.
PubMed PMID:26677978

Paweletz, CP, Sacher, AG, Raymond, CK, Alden, RS, O’Connell, A, Mach, SL, Kuang, Y, Gandhi, L, Kirschmeier, P, English, JM, Lim, LP, Jänne, PA, Oxnard, GR. Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients. Clin. Cancer Res. 2016;22 (4):915-22.
PubMed PMID:26459174

2015

Janiszewska, M, Liu, L, Almendro, V, Kuang, Y, Paweletz, C, Sakr, RA, Weigelt, B, Hanker, AB, Chandarlapaty, S, King, TA, Reis-Filho, JS, Arteaga, CL, Park, SY, Michor, F, Polyak, K. In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer. Nat. Genet. 2015;47 (10):1212-9.
PubMed PMID:26301495

Soucheray, M, Capelletti, M, Pulido, I, Kuang, Y, Paweletz, CP, Becker, JH, Kikuchi, E, Xu, C, Patel, TB, Al-Shahrour, F, Carretero, J, Wong, KK, Jänne, PA, Shapiro, GI, Shimamura, T. Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition. Cancer Res. 2015;75 (20):4372-83.
PubMed PMID:26282169

Tolaney, SM, Tan, S, Guo, H, Barry, W, Van Allen, E, Wagle, N, Brock, J, Larrabee, K, Paweletz, C, Ivanova, E, Janne, P, Overmoyer, B, Wright, JJ, Shapiro, GI, Winer, EP, Krop, IE. Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer. Invest New Drugs. 2015;33 (5):1108-14.
PubMed PMID:26123926

Thress, KS, Paweletz, CP, Felip, E, Cho, BC, Stetson, D, Dougherty, B, Lai, Z, Markovets, A, Vivancos, A, Kuang, Y, Ercan, D, Matthews, SE, Cantarini, M, Barrett, JC, Jänne, PA, Oxnard, GR. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat. Med. 2015;21 (6):560-2.
PubMed PMID:25939061

Castellanos-Rizaldos, E, Paweletz, C, Song, C, Oxnard, GR, Mamon, H, Jänne, PA, Makrigiorgos, GM. Enhanced ratio of signals enables digital mutation scanning for rare allele detection. J Mol Diagn. 2015;17 (3):284-92.
PubMed PMID:25772705

Bhanot, H, Reddy, MM, Nonami, A, Weisberg, EL, Bonal, D, Kirschmeier, PT, Salgia, S, Podar, K, Galinsky, I, Chowdary, TK, Neuberg, D, Tonon, G, Stone, RM, Asara, J, Griffin, JD, Sattler, M. Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells. Leukemia. 2015;29 (7):1555-1563.
PubMed PMID:25703587

2014

Jänne, PA, Ou, SH, Kim, DW, Oxnard, GR, Martins, R, Kris, MG, Dunphy, F, Nishio, M, O’Connell, J, Paweletz, C, Taylor, I, Zhang, H, Goldberg, Z, Mok, T. Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial. Lancet Oncol. 2014;15 (13):1433-41.
PubMed PMID:25456362

Parfenov, M, Pedamallu, CS, Gehlenborg, N, Freeman, SS, Danilova, L, Bristow, CA, Lee, S, Hadjipanayis, AG, Ivanova, EV, Wilkerson, MD, Protopopov, A, Yang, L, Seth, S, Song, X, Tang, J, Ren, X, Zhang, J, Pantazi, A, Santoso, N, Xu, AW, Mahadeshwar, H, Wheeler, DA, Haddad, RI, Jung, J, Ojesina, AI, Issaeva, N, Yarbrough, WG, Hayes, DN, Grandis, JR, El-Naggar, AK, Meyerson, M, Park, PJ, Chin, L, Seidman, JG, Hammerman, PS, Kucherlapati, R, Cancer Genome Atlas Network. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc. Natl. Acad. Sci. U.S.A. 2014;111 (43):15544-9.
PubMed PMID:25313082

Luke, JJ, Oxnard, GR, Paweletz, CP, Camidge, DR, Heymach, JV, Solit, DB, Johnson, BE, Cell Free DNA Working Group. Realizing the potential of plasma genotyping in an age of genotype-directed therapies. J. Natl. Cancer Inst. 2014;106 (8):.
PubMed PMID:25106647

Paweletz, CP, Jänne, PA. Monitoring cancer through the blood. Cancer. 2014;120 (24):3859-61.
PubMed PMID:25103496

Muvaffak, A, Pan, Q, Yan, H, Fernandez, R, Lim, J, Dolinski, B, Nguyen, TT, Strack, P, Wu, S, Chung, R, Zhang, W, Hulton, C, Ripley, S, Hirsch, H, Nagashima, K, Wong, KK, Jánne, PA, Seidel-Dugan, C, Zawel, L, Kirschmeier, PT, Middleton, RE, Morris, EJ, Wang, Y. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol. Cancer Res. 2014;12 (7):1055-66.
PubMed PMID:24752990

Oxnard, GR, Paweletz, CP, Kuang, Y, Mach, SL, O’Connell, A, Messineo, MM, Luke, JJ, Butaney, M, Kirschmeier, P, Jackman, DM, Jänne, PA. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin. Cancer Res. 2014;20 (6):1698-1705.
PubMed PMID:24429876

Lu, G, Middleton, RE, Sun, H, Naniong, M, Ott, CJ, Mitsiades, CS, Wong, KK, Bradner, JE, Kaelin, WG Jr. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014;343 (6168):305-9.
PubMed PMID:24292623