Pasi Jänne, MD, PhD

Photo of Pasi Janne, MD, PhD
Director, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute
Professor of Medicine, Harvard Medical School
Director, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute

A preeminent translational oncologist whose work has fundamentally changed the way lung cancer is treated, in his research Dr. Jänne combines laboratory-based studies with translational research and clinical trials of novel therapeutic agents in patients with lung cancer. In 2004, he was the co-first author of a seminal study that identified somatic mutations in EGFR in non-small cell lung cancer (NSCLC) tumors and demonstrated their association with the efficacy of the EGFR tyrosine kinase inhibitor gefitinib.

Dr. Jänne’s current focus is on understanding mechanisms of acquired resistance to targeted therapies in a variety of cancers, development of new and novel models to study resistance, and developing new therapeutic strategies to effectively treat drug-resistant cancers. His studies helped identify MET amplification as a novel EGFR inhibitor resistance mechanism and have now inspired several clinical trials combining EGFR and MET inhibitors for lung cancer patients. Dr. Jänne has also extensively studied strategies to overcome mechanism of resistance mediated by EGFR mutations and led the first-in-human clinical trial of the mutant selective EGFR inhibitor, which received regulatory approval in 2015.

Dr. Jänne received an MD and PhD from the University of Pennsylvania, and completed his internship and residency in medicine at Brigham and Women’s Hospital in Boston. In 2002, he earned a master’s degree in clinical investigation from Harvard University. He has received several awards for his research, including from Uniting Against Lung Cancer, American Lung Association, and the Bonnie J. Addario Lung Cancer Foundation. He is an elected member for the American Society of Clinical Investigation (2009), American Association of Physicians (2016), and the Finnish Academy of Science and Letters (2016). He is also the recipient of 2010 American Association of Cancer Research Richard and Hinda Rosenthal Memorial and Team Science awards, the 2018 Waun Ki Hong Award for Outstanding Achievement in Translational and Clinical Cancer Research, and the 2018 ESMO Translational Research Award. In 2017 Dr. Jänne was awarded an American Cancer Society Clinical Research Professorship.